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Upon binding, IGF-1R undergoes autophosphorylation, recruiting insulin receptor substrate (IRS) proteins and Shc adaptor molecules
They selectively feed Bifidobacteria and Akkermansia, the same microbes that are associated with GLP-1 enhancement
Because deficiencies in these nutrients may produce similar symptoms, blood testing is often needed to determine whether vitamin B12, folate, or both are low
This recognition encouraged preclinical studies aiming to investigate both mechanistic aspects and intervention strategies to characterize and target this biological axis in conditions affecting muscle, brain, the immune system, and metabolic diseases
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