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This dual mechanismdirect anti-inflammatory action plus weight-driven metabolic improvementmay explain why semaglutide users often report feeling less fatigued and more resilient to stress, hallmark signs of normalized cortisol function

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Special consideration is given to patients with established fecal incontinence, known anal sphincter muscle injury (such as after obstetric injury) or diarrheal conditions (i.e., Crohns disease)

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