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Berberine, an isoquinoline alkaloid from Berberis spp., has demonstrated promising antioxidant activity via promoting heme oxygenase-1 (HO-1) expression, activating Nrf2/AMPK/SIRT1 signaling, inhibiting the NLRP3 inflammasome, balancing glutathione levels, and regulating mitochondrial redox processes (Sunhe et al., 2024

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We went through a period of so many years where the returns kept declining, excluding the COVID impact in the middle, said Kevin Dondarski, principal for life sciences strategy at Deloitte Consulting