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This triggers the gastrocolic reflex, a natural response where stomach filling signals the colon to make room by initiating a bowel movement

Dig Dis Sci (2011) 56(6):172934.10.1007/s10620-011-1615-0 45 ShahMLawJHMichelettoFSathananthanMDalla ManCCobelliCet alContribution of endogenous glucagon-like peptide 1 to glucose metabolism after Roux-en-Y gastric bypass

Orforglipron does not appear to require the same food timing restrictions

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