does semaglutide build up over time Long half-life leads to increasing side effect for to 8 weeks : r/ 4-5 months progress (~50lbs) :

Nausea, vomiting, constipation, or diarrhea that persist beyond the first few weeks may indicate your GI system is more sensitive to the dual-pathway activation

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Fluid needs depend on your activity level, sex, and environment, among other factors

However, most available randomized data derive from subgroup, post hoc, or exploratory analyses rather than trials specifically designed to evaluate dual therapy in HF populations