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Meutim, pod odreenim ekstremnim uvjetima, kao to su jake kiseline ili jake luine, ili pod utjecajem imbenika poput visoke temperature i svjetlosti, njegova molekularna struktura moe se promijeniti, to dovodi do promjena u kemijskim svojstvima i time utjee na njegovu bioloku aktivnost
Later, this question was further explored by Mutvei et al
doi:10.1124/jpet.121.000567 About TFA salt Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC)
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