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As for the stopper, its sealing ability gets compromised

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2.2 Restricting the recruitment and localization of TAMs Macrophages enter tumors under the action of a variety of chemokines, such as CC motif chemokine 2 (CCL2), CCL3, CCL4, CCL5, colony-stimulating factor-1, and vascular endothelial growth factor (VEGF), based on this the strategy of targeting TAMs to treat tumors can also block TAMs entry into tumors by targeting these chemokines that recruit macrophages (12)