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Unbound protein was washed out with 10 ml of binding buffer

In LEADER, absolute MACE reduction was larger in women (2.4%) than in men (1.5%) and remained significant in participants achieving baseline HbA1c 7% [28, 29]

To test this possibility, we performed cgMD simulations of GLP-1R in active versus inactive conformations in a model mammalian plasma membrane using the latest Martini 3 forcefield and cholesterol parameters, identifying specific receptor sites with high cholesterol occupancies and residence times

For all MAX2 and At SMAX1 proteins, purification was done on KTA pure systems, first by affinity purification on HisTrap HP 5 mL (Cytiva) column, followed by StrepTrap XT 5 mL (Cytiva) column and then by size-exclusion chromatography (SEC) on HiLoad 16/600 Superdex 200 pg (Cytiva)