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Thats where Vitamin B12 comes in

The NAD connection: sustained NAD availability from NNMT inhibition has downstream effects that are not fully mapped across cell types

This might explain the reticence that leads to the following appalling statistics from the most recent research from PAS on people with a Pernicious Anaemia diagnosis : 17% waited up to 1 year for correct diagnosis 19% waited 5 years 33% waited 5 years or more 4% waited 10 years 14% waited 10 years or more for their diagnosis 44% were originally misdiagnosed with MS/ depression/ ME/ Chronic Fatigue Syndrome The good news is that there is research being carried out that clearly shows a good reason why some of us cannot survive on the 3- month regime that many in the UK are stuck with (and having to resort to self-injection just to be able to stop deteriorating)- and the Pernicious Anaemia Society are responsible for initiating this research

A: Frequency depends on your individual health goals and your providers recommendation