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Our study has important implications for our understanding of enzymatically active and inactive glutaredoxins and could be useful for the design and optimization of artificial glutaredoxins, glutaredoxin-coupled fluorescent redox sensors and transition-state inhibitors

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Liposomal nanoparticles encapsulating miR-29a-3p (lipo@miR-29a-3p) were engineered for translational use, exhibiting significant anticancer efficacy and excellent biocompatibility in a mouse model [316]

In addition, NADPH generation via glutamine metabolism in cancer cells supports redox homeostasis by maintaining the cytosolic NADPH pool used to restore oxidized glutathione 29 (Fig