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Finally, a significant drug main effect ( p = 0.01) was found for total ghrelin, suggesting that total ghrelin concentrations during the oral cannabis session were higher than the smoked and vaporized cannabis sessions

Crucially, Crat knockout experiments partially reversed these metabolic improvements, establishing CrAT-mediated SREBP1c inhibition as a key mechanism through which L-carnitine counteracts de novo lipogenesis