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Eur Heart J 2011

Instead of increasing every four weeks, extending each dose level to six or eight weeks allows the body more time to adapt while the pyridoxine handles the acute nausea component

Interestingly, males display lower plasma folate levels than females (120122), and only males demonstrate a positive correlation between the folate deficiency risk scores calculated from the polymorphisms in the folate pathway genes SLC19A1 and MTHFR (123)

Theres also the potential for serious complications such as septicaemia, infective endocarditis, and blood infections as a result of the treatments being given by those without health qualifications, says Professor Davids