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While medications maintain sustained, supraphysiologic hormone levels and typically produce significant weight reduction and HbA1c decreases, food-stimulated GLP-1 is released in brief pulses after meals and rapidly degraded within minutes, resulting in smaller metabolic improvements

The introduction of highly efficacious and generally safe medications for obesity treatment, such as GLP-1RAs, has disrupted this framework, reframing obesity as a medical issue that can be treated pharmacologically

Opportunities Expanding Use in Obesity Management The growing use of GLP-1 analogues for the treatment of obesity is one of the largest opportunities

This is an advanced strategy that requires already having a solid baseline protocol established, but it demonstrates the flexibility that understanding pharmacokinetics provides