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ACHIEVE-2 (NCT06192108) A comparator trial evaluating orforglipron versus dapagliflozin (an SGLT-2 inhibitor) in adults with type 2 diabetes

Additionally, while our findings are reassuring with regard to effects on newborn birthweight, we will need to exclude any potential long-term impact on childhood metabolic health. For more information: Jacqueline Maya, MD , can be reached at [email protected].

By recognizing these factors, we can take proactive steps to support gut health and prevent related issues

Experimental models demonstrate that restoring glutathione normalizes mitochondrial redox status and improves endothelial and cardiovascular function, supporting a causal role for mitochondrial glutathione depletion in cardiovascular aging (17-18)