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The majority of Fos-positive cells were in non=TH+ cells (identified by white arrows), with few TH+ cells demonstrated Fos immunoreactivity in response to nicotine (identified by yellow arrows)

During the treatment of RA, NPs, GLP-1RAs@NPs or GLP-1RAs@NPs-WYRGRL were injected subcutaneously into the skin of the hind paws of rats, or MN and MN/GLP-1RAs@NPs-WYRGRL were used to puncture the skin and left in place

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Future studies may examine whether these reproductive improvements translate into higher pregnancy rates, improved live birth outcomes, and long-term reproductive benefits