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Getting used to this sensation might take time

Known colloquially as Ozempic face, these changes include facial fat pad deflation, skin laxity, and an accelerated ageing appearance [2]

What varies is individual tolerance, and that varies enormously

Compared with lixisenatide, exenatide twice daily, liraglutide, albiglutide and dulaglutide, semaglutide is associated with highest nausea and vomiting rates, yet also with highest rates of improvement in glycemic control and weight loss (132)