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LCACs also perturb Ca 2+ homeostasis in the cytoplasm and have been shown to disrupt myocardial contractility and electrophysiology, thereby inducing cardiomyopathy and arrhythmias [294]

Individuals with DNA repair defects accumulate more DNA damage, resulting in heightened DNA damage responses, including hyperparylation

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These innovative approaches aim to overcome the limitations of natural compound-based therapies and optimize their therapeutic benefits for neuroprotection in PD patients