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Inflamed gastrointestinal lining will impair nutrient and thyroid absorption, thus leading to nutrient deficiencies and possibly even thyroid hormone deficiency due to impaired absorption

Abbreviations AAP: American Academy of Pediatrics AC: Abdominal Circumference ADA: American Diabetes Association ALT: Alanine Aminotransferase AST: Aspartate Aminotransferase ASCVD: Atherosclerotic Cardiovascular Disease AOM: Anti-Obesity Medication AOMs: Anti-Obesity Medications BMD: Bone Mineral Density BMI: Body Mass Index BP: Blood Pressure CPCG: Canadian Clinical Practice Guidelines CKD: Chronic Kidney Disease CRP: C-Reactive Protein DBP: Diastolic Blood Pressure eGFR: Estimated Glomerular Filtration Rate EASO: European Association for the Study of Obesity FFM: Fat-Free Mass GGT: Gamma-Glutamyl Transferase GI: Gastrointestinal GLP-1: Glucagon-like Peptide-1 GIP: Glucose-dependent Insulinotropic Polypeptide HbA1c: Hemoglobin A1c HF: Heart Failure HFpEF: Heart Failure with Preserved Ejection Fraction HOMA-IR: HOmeostatic Model Assessment for Insulin Resistance HRQoL: Health-Related Quality of Life ICER: incremental cost-effectiveness ratio LDL: Low-Density Lipoprotein MASLD: Metabolic Dysfunction-Associated Steatotic Liver Disease MASH: Metabolic Dysfunction-Associated Steatohepatitis MACE: Major Adverse Cardiovascular Events MHO: Metabolically Healthy Obese MUO: Metabolically Unhealthy Obese PA: Physical Activity PCOS: Polycystic Ovary Syndrome QALYs: Quality-adjusted life years QoL: Quality of Life RCT: Randomized Controlled Trial RMR: Resting Metabolic Rate SBP: Systolic Blood Pressure T1D: Type 1 Diabetes T2D: Type 2 Diabetes WC: Waist Circumference WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index References Bray GA, Kim KK, Wilding JPH, World Obesity Federation (2017) Obesity: a chronic relapsing progressive disease process

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