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Figure 3 Moreover, increased systematic translocation of intestinal metabolites, bacterial particulates, or even microbiota through the damaged intestinal tract (the leaky gut) heightens systemic inflammatory reactions such as Th17/Treg disorder, interleukin-6, IL-1, and tumor necrosis factors alpha that are being implicated in the etiology of depression

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Materials and methods: This study aims to analyze the vascular function and aging status of the aorta in naturally aged mice and progeroid model mice following FOXO4-DRI injection