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Although the above discussed studies suggested a considerable association between the selenium-induced GPx level and the radiation resistance of cultured cells and murine models, it can be argued that the direct cause and effect relationship between GPx activity/expression and radiation toxicity was lacking in these studies

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In mammalian cells, as in archaeal and bacterial cells, amino acid-derived bacterial metabolites such as S-adenosylmethionine, polyamines, and nitric oxide are involved in physiological functions related to methyl donor functions, cellular growth, and cell respiration, respectively