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Additionally, previous research has demonstrated that ghrelin can enhance blood circulation in the digestive system in a sepsis model and potentially prevent the apoptosis of stomach mucosa cells by regulating apoptosis-related elements in gastric tissues, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X (Bax), and caspase-3 proteins (112)

10.1002/hep.25656

This finding might also explain the decreased LDL susceptibility to oxidation observed in patients with homocystinuria

Unique role of IGF-1R in cancer The IGF-1R is a phylogenetically conserved receptor TK and belongs to the insulin receptor family, involving also the insulin receptor (IR), hybrid receptors and the IGF-2R/mannose 6-phosphate receptor