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Retatrutide represents a novel generation of research compounds in the anti-obesity and antidiabetic field, characterized by its unique mechanism of action involving the simultaneous activation of three metabolically relevant receptors: the GCG-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the GCG receptor (GCGR)

Eating smaller, more frequent meals and avoiding high-fat foods reduces nausea severity

The researchers also couldn't account for some factors, such as socioeconomic status or lifestyle choices, that could affect the results

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