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Obesity is a major part of the problem, its complications including chronic kidney disease, hypertensive disease, stroke, and liver disease negatively impacting quality but also quantity of life as life expectancy decreases as body mass index (BMI) increases [3]

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Notably, DPP-4 is expressed on the surface of endothelial cells, including those located directly adjacent to GLP-1 secretion sites

Animals, Diet, and Drugs Seven-week-old male CD-1 mice (The Experimental Medicine Centre (EMC) at the Medical University of Lublin, Poland) were housed in groups of four per cage under standard conditions, i.e., a constant temperature of 2021 C 1 C, humidity at 60 10%, with a 12-h light/dark cycle