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Abbreviations A: Amyloid-beta AD: Alzheimer's disease APOE: Apolipoprotein E APP3: Aminopeptidase P3 ARIA: Amyloid-related imaging abnormalities BBB: Bloodbrain barrier CNS: Central nervous system CSF: Cerebrospinal fluid FADD: FAS-associated death domain GABA: Gamma-aminobutyric acid IFN-: Interferon- IKK: IB kinase JNK: C-Jun N-terminal kinase MAPK: Mitogen-activated protein kinase MRI: Magnetic Resonance Imaging mAChR-LTD: Muscarinic acetylcholine receptordependent long-term depression PI3K: Phosphatidylinositol 3-kinase PRh: Perirhinal cortex PMG: Physcion-8-O--d-monoglucoside RA: Rheumatoid arthritis RIP: Receptor-interacting protein solTNF: Soluble tumor necrosis factor tmTNF : Transmembrane tumor necrosis factor TNFR1: Tumor necrosis factor receptor 1 TNFR2: Tumor necrosis factor receptor 2 TNF-: Tumor necrosis factor- TRADD: TNF receptor-associated death domain TRAF2: TNF receptor-associated factor 2 TREM2: Triggering Receptor Expressed on Myeloid Cells 2 WHO: World Health Organization References Global action plan on the public health response to dementia 20172025

The appropriate dosage can vary significantly depending on several factors, including the treated condition, individual health status, and concurrent medication use

United Nations Publication: New York, NY, USA, 2020