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FIGURE 1 Although both animals and humans possess endogenous antioxidant defense systems, the prevailing view remains that additional antioxidant support must come from exogenous sources, particularly diet

Despite these challenges, new therapies based on elucidated genes have been developed in recent years, such as gene replacement, gene editing and translating oligonucleotides

KPV studies report effective anti-inflammatory concentrations in cell culture models at nanomolar to low micromolar ranges [7]

Figure 9 In addition, to the interactive effect of sex and APOE described above there were strong sex effects observed on L-carnitine gut metabolites, and other TMA-containing metabolites, and acylcarnitines in the plasma,brain, and liver (Supplementary Table S7)