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Description

10.1046/j.1471-4159.2001.00383.x J

Many individuals still benefit from the use of insulin, including those with type 1 diabetes (T1D), patients with newly diagnosed T2D with an elevated A1c, and those with access/cost concerns regarding branded medications

However, the insufficient stability of acid-cleavable linkers severely limits their application in ADCs, and a phenylketone-derived hydrazone linker was hydrolyzed with a t 1/2 = 2 days in human and mouse plasma