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The mitochondria in RGCs from glaucoma subjects and rodent glaucoma models were smaller, rounder, and more fragmented, suggesting a link between glaucoma, iron levels, and mitochondrial dysfunction (321)

Kubota, et al., A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice

Additionally, while preclinical studies have demonstrated encouraging results, most research remains in early stages, and the lack of reliable biomarkers for monitoring ferroptosis complicates clinical application