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For the majority of patients, injectable dulaglutide was selected due to the ease of use of the delivery device and the absence of a need for titration to reach the therapeutic dose

The decline of estrogen and progesterone withdraws hormonal signals that had been governing cellular energy regulation, mitochondrial function, and inflammatory tone across the brain, vasculature, adipose tissue, and skeletal muscle simultaneously

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The emergence of these novel agonists not only opens new avenues for the treatment of obesity and diabetes but also provides clear directional guidance for future drug development, preclinical, and clinical research [43,44,45]