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In the study, people on Ozempic had a slightly higher chance of being diagnosed with migraines compared to those on glipizide

Clinical data show that weight regain is common after GLP-1 medications are discontinued, including a STEP 1 trial extension where participants regained about two-thirds of prior weight loss one year after stopping semaglutide and lifestyle intervention

Second, chemical modifications (fatty acid conjugation, unnatural amino acids, DPP-IV-resistant substitutions) are essential for converting short-acting natural peptides into therapeutically useful molecules

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