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246 Its peak concentration appears during the late G1 and G1/S cell cycle stages

Mutations in the MC4R gene (rs17782313) and the GIPR gene (rs1800437) also influence appetite regulation and GLP-1 effectiveness

Although MR analysis did not establish a genetic causal link between metformin and reduced AD risk, transcriptomic validation confirmed that metformins predicted pathway interactions align with real-world gene expression changes in MCI patients, reinforcing its biological relevance