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IUBMB Life (2018) 70(6):55362

J Clin Hypertension

Snoek FJ, Anarte-Ortiz MT, Anderbro T, Cyranka K, Hendrieckx C, Hermanns N, et al

In the INSPIRE cohort of 106 patients with advanced solid tumors treated with pembrolizumab (anti-PD-1 antibody) (NCT03702309) (235), higher serum choline levels were associated with augmented CD8 - T cells and B cells in the tumor stroma, as well as an elevated CD3 + CD8 + cytotoxic T cells to CD3 + CD8 - FOXP3 + T regulatory cells ratio in the tumors (235)