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Studies addressing the effects of ES as well as nutritional interventions in both males and females were included, however the literature to date mostly fails to test whether the efficacy of the nutritional intervention is sex-specific

PMID: 25205085

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In the phase 2 trial of retatrutide in individuals with T2D and overweight/obesity, retatrutide caused large reductions in circulating amino-acids, although lean mass and physical function were not directly assessed [46]