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Its established molecular architecture and documented metal-binding properties have made it a valuable reference compound for studies examining ligand-metal interactions, metallopeptide pharmacology, structure-function relationships, and copper-dependent regulatory mechanisms.

Intracellularly, it is involved in the biosynthesis of nicotinamide and adenine dinucleotide, but it is also released extracellularly, where it appears to have a wide range of effects, including stimulating angiogenesis and endothelial cell proliferation

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Their effectiveness has led to widespread use among those looking to shed significant pounds, but that success sometimes comes with a surprising side effect: changes to facial appearance