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Common reasons for exclusion were probiotic supplementation not specific to Akkermansia, no linking to IR or other metabolic disorders, or using other plant derived supplements to trigger natural Akkermansia growth

Studies have shown that lutein effectively suppressed various skin inflammatory responses in UV-irradiated keratinocytes, IFN-/TNF--stimulated human keratinocyte cell line (HaCaT) cells, and LPS-treated macrophages, reducing the production of IL-6, COX-2, and matrix metalloproteinase-9 (MMP-9)