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Several treatments that can therapeutically target these pathways have been tested in preliminary clinical trials

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18 mTORC1 integrates signals from nutrients and growth factors to regulate various anabolic processes, including protein synthesis, nucleotide production, lipid biosynthesis, and glycolysis, while inhibiting catabolic processes such as autophagy by phosphorylating ULK1/2 and sequestering lysosomal enzymes

temper M1 macrophage dominance and promote M2 macrophage healing phenotypes Immunomodulatory effects Reset dysregulated immune loops, recruit and orchestrate reparative cells, reduce chronic demolition signals, and favor reconstruction signals