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Evidence indicates that these interfaces coordinate Ca 2+ signaling microdomains, non-vesicular lipid transfer, and mitochondrial bioenergetics to maintain proteostasis, among other functions (Dematteis et al., 2024

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6.1 Recent clinical trials targeting RCD pathways in melanoma and emerging evidence Recent advances in clinical research have witnessed the initiation of multiple trials evaluating RCD-targeted therapies in melanoma, providing preliminary evidence for their safety, efficacy, and predictive biomarkers