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Although de novo polyamine synthesis from ornithine represents the major source of intracellular polyamines, transport of extracellular polyamines into cells is accomplished via the SLC45A4 encoded transporter which is a member of the glycoside-pentoside-hexuronide cation symporter family of transporters
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CPTI serves as a downstream effector of PAX3-FKHR in ARMS CPTI expression is regulated by a different pathway in aggressive alveolar rhabdomyosarcoma (ARMS)
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