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GLP-1 RAs have been shown good promise in the treatment of type 2 diabetes and can also induce weight loss, which is thought to be related to its peripheral effect of delaying gastric emptying and its central anorexigenic effects (4, 18)

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In conclusion, compared with existing observational studies, MR with SMR simulates the process of random assignment of parental alleles to offspring, and thus can effectively reduce confounding-induced bias and enhance causal inferences [7]