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Duration varies based on dosage, hydration, preexisting digestive conditions, and meal timing

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(A) Schematic showing time-course qRT-PCR and transcriptomic analysis following germline-specific degradation of LAG-1

Similarly, Adikwu and Bokolo 43 recorded a significant rise in MDA level and a significant decline in GSH level and SOD, CAT and GPx activities in the kidney tissue of MTX-treated rats, and they attributed these results to free radicals production, which might be the probable reason for the reduction of the anti-oxidant activities