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In one systematic review, roughly half to two-thirds of perimenopausal women reported hot flashes or night sweats, so overlap is the rule, not the exception

If one or two SSRI trials fail, the most effective next steps are 1) switching from an SSRI to Clomipramine, 2) augmenting the SSRI with a second, adjunctive medication, or 3) switching to a second-line standalone medication

For that reason, the uMMA test can predict ones path toward permanent neurological impairment

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