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The MASH mouse and hamster work published by Briand and colleagues in 2026 showed dose-dependent reductions in body weight, hepatic steatosis, and liver enzymes that exceeded what dual agonists produced in the same models (Briand et al., Obesity, 2026)

While early data is promising and many anticipate that retatrutide may soon be available by prescription through legitimate medical channels, it is still in phase 3 clinical trials and has not been approved by the FDA for prescription use or sale

Weight loss was discovered as a beneficial side effect during clinical trials, leading Novo Nordisk to develop Wegovy as a dedicated obesity treatment using the same molecule at higher doses

The lyophilized form is intentional