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Note: Published findings for these peptides are predominantly preclinical and should be interpreted within the limits of the model system used

To further elucidate the role of these genes in T1D pathology, future studies should utilize islets from patients harboring these variants or genetically engineered stem cell-derived islets and treat them with various stressors to delineate unique responses

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Note: While TB-500 is often discussed as thymus-derived, it is a synthetic fragment not naturally produced in the thymus