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Crystals were cryoprotected by addition of ethylene glycol at a final concentration of 10% prior to harvesting

Step 2: Open-Period You must submit your Full Proposal during the Open-Period

Efficacy in humans is being examined in further structured studies

Key findings included: Nearly 16% non-placebo-adjusted weight loss on 2.4 mg weekly berobenatide No weight-loss plateau observed through 32 weeks of extension treatment Successful transition from weekly induction to monthly maintenance dosing Favorable gastrointestinal tolerability despite rapid dose escalation These results provide proof-of-concept for monthly GLP-1 therapy while maintaining competitive efficacy