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Rybelsus became the first FDA-approved oral GLP-1 agonist, though with a catch, its bioavailability was only 0.4-1% of the injectable version. Patients needed to take it daily on an empty stomach with minimal water, waiting 30 minutes before eating or drinking anything else

PLoS One 4 , e5351 (2009)

Natco Pharma will launch its Semaglutide injection (multi dose vials) in the domestic market on Saturday

Warnings and precautions include acute pancreatitis, acute gallbladder disease, hypoglycemia, acute kidney injury, hypersensitivity reactions, diabetic retinopathy complications in patients with type 2 diabetes, increased heart rate, and suicidal behavior and ideation, and pulmonary aspiration during general anesthesia or deep sedation