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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)
Nevertheless, multiple degradation-resistant and structurally distinct GLP-1RAs do not generate the same GLP-1 metabolites yet reduce blood pressure, increase heart rate, inhibit enterocyte chylomicron secretion and reduce the extent of myocardial infarction in rats and mice through mechanisms requiring the canonical GLP-1R [99, 105,106,107,108]
R., Lee, J., Chu, H., Jeong, K
If you suspect your throat symptoms may be related to Saxenda, you can report this as a suspected side effect through the MHRA Yellow Card scheme (yellowcard
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