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Protein arginylation is regulated during SARS-CoV2 infection

SARS-CoV-2 infection reprograms host folate and one-carbon metabolism at the PTM level to support de novo purine synthesis for replication of viral genome, through bypassing the viral shutoff of host translation 37

The possible mechanisms for the generation of acanthocytes include abnormal phospholipid metabolism and an increased ratio of cholesterol to phosphatidylcholine in the cell membrane, both of which can cause abnormalities in the erythrocyte membrane ( In HAPC rats, an increase in EOF was observed, accompanied by decreased resistance of cells to hemolysis in hypotonic solutions

Funding This work has been supported by a recurring unrestricted gift from the Dr