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3.3 Diagnosis Diagnosis of diabetic sarcopenia was based on the presence of criteria of low muscle strength (probable sarcopenia) and low muscle mass (confirmed sarcopenia) using methods available to any clinical visit such as dynamometry, the chair stand test, and BMI-adjusted calf circumference

The decision likely didnt come as a complete surprise to Amgen, as it followed a 10-2 advisory committee vote in October against the drug

[4] This stepwise titration schedule was established in clinical trials to find the most effective and safe dose for patients while managing side effects

doi: 10.1016/j.jss.2009.03.027