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Bicuculline is a competitive antagonist of GABAARs primarily on the ionotropic GABAARs, ligand-gated ion channels, and the passing of chloride ions across the cell membrane [230]

Piperine is used in the current study as it is known for the enhancement of bioavailability of drug component from ancient time and in the traditional system of medicine Ayurveda ( Results presented in Table 10 indicate the values of pharmacokinetic parameters obtained due to oral administration of the formulations F1 and F2 calculated with respect to the marker compounds viz

It's important to note, however, that multiple factors can cause these symptoms