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In general, disordered domains are unsuitable targets for potent peptide binding because of the lack of well-defined binding surfaces, conformational flexibility, and associated entropic penalties 60,61

The second co-stimulatory signal arises from the engagement of B7.1 (CD80) and B7.2 (CD86) molecules on APCsincluding activated macrophages, dendritic cells, and B cellswith CD28 on T cells

There was no significant difference in vasorelaxation induced by 0.1 or 1 g/ml BPC 157 in aorta without endothelium

This peptide is examined in controlled in vitro research settings, including receptor interaction studies and molecular signaling pathway analysis