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Semaglutide shares 94% structural homology with native human GLP-1 but has been modified to resist degradation by the DPP-4 enzyme
10.1172/jci95147 J
A Nature Medicine review published in January 2026 described GLP-1 medicines as "being prescribed to growing numbers of patients worldwide" for an expanding list of indications and noted that "new, more effective molecules with optimised pharmacokinetics produce greater weight loss and some may be more effective for various metabolic disorders, through incorporation of one or more additional peptide epitopes." The clinical pipeline includes 39 GLP-1 receptor agonist drugs in development across 34 companies, with only seven coming from the top 20 pharmaceutical firms
Frequently Asked Questions Is the GLP-1 in compounded medications the same as the GLP-1 your body naturally makes
